Mecozol 60 ml

Dosage & Administration

Tablet and Suspension:

Trichomoniasis (Adults & Children over 10 yrs)-

• 200 mg tid or 400 mg bid for 7 days

• 800 mg in the morning and 1-2 gm at night for 2 days

• 2 gm as a single dose for 1 days

Trichomoniasis (Children)-

• Children 7-10 yrs: 100 mg tid

• Children 3-7 yrs: 100 mg bid

• Children 1-3 yrs: 50 mg tid

Intestinal amoebiasis (Adults & Children over 10 yrs)-

• 800 mg tid for 5 days

Intestinal amoebiasis (Children)-

• Children 7-10 yrs: 400 mg tid

• Children 3-7 yrs: 200 mg qid

• Children 1-3 yrs: 200 mg tid

Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-

• 400-800 mg tid for 5-10 days

Extra-intestinal & Asymptomatic amoebiasis (Children)-

• Children 7-10 yrs: 200-400 mg tid

• Children 3-7 yrs: 100-200 mg qid

• Children 1-3 yrs: 100-200 mg tid

Giardiasis (Adults & Children over 10 yrs)-

• 2 gm once daily for 3 days

Giardiasis (Children)-

• Children 7-10 yrs: 1 gm once daily

• Children 3-7 yrs: 600-800 mg once daily

• Children 1-3 yrs: 500 mg once daily

• Acute ulcerative  gingivitis (Adults & Children over 10 yrs)-

• 200 mg tid for 3 days

• Acute ulcerative  gingivitis (Children)-

• Children 7-10 yrs: 100 mg tid

• Children 3-7 yrs: 100 mg bid

• Children 1-3 yrs: 50 mg tid

• Acute dental infections (Adults & Children over 10 yrs)-

• 200 mg tid for 3-7 days

• Bacterial Vaginosis (Adults & Children over 10 yrs)-

• 400 mg bid for 7 days

• 2 gm as a single dose for 1 days

• Leg ulcers and pressure sores (Adults & Children over 10 yrs)-

• 400 mg tid for 7 days

• Anaerobic infections (Adults & Children over 10 yrs)-

• 800 mg initially and then 400 mg tid for 7 days

• Anaerobic infections (Children)-

• Children 1-10 yrs: 7.5 mg/kg tid

• Surgical prophylaxis (Adults & Children over 10 yrs)-

• 400 mg tid started 24  hours before  surgery for 1 days

• Surgical prophylaxis (Children)-

• Children 1-10 yrs: 7.5 mg/kg tid

Vaginal Gel:

The recommended dose is one applicator full of Metronidazole gel (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days. For once a day dosing, Metronidazole gel should be administered at bedtime.

Suppository:

Anaerobic Infections-

• Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours.

• Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose.

Surgical Prophylaxis-

• Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures.

• Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures.

IV Infusion:

Metronidazole intravenous infusion requires no dilution and should not be mixed with any other drugs prior to administration.

Adults and children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute and a maximum of 4 g should not be exceeded during a 24-hour period. Treatment for 7 days is sufficient for most patients, but treatment can be extended, especially for cases where reinfection is likely. For surgical prophylaxis, administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours.

Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute.

Interaction

Disulfiram: Patients who use metronidazole and disulfiram at the same time have reported psychotic reactions.

Alcohol: alcoholic beverages and alcohol-containing drugs should not be consumed during treatment and for at least one day after treatment, because disulfiram-like reactions (anti-abuse effects) (flushing, vomiting, tachycardia) may occur. Oral anticoagulant therapy (warfarin type): The anticoagulant effect is enhanced, and the liver catabolism is reduced, leading to an increased risk of bleeding. In the case of co-administration, prothrombin time should be monitored more frequently and anticoagulant therapy should be adjusted during metronidazole treatment.

Lithium: Metronidazole can increase the content of lithium in the plasma.

Cyclosporine: When co-administration is required, serum cyclosporine and serum creatinine should be closely monitored.

Phenytoin or phenobarbital: increased elimination of metronidazole leads to decreased plasma levels.

5 Fluorouracil: The clearance rate of 5 Fluorouracil is reduced, which increases the toxicity of 5 Fluorouracil.

Busulfan: Metronidazole can increase plasma levels of busulfan, which can cause severe busulfan toxicity.

Contraindications

Patients having a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives should avoid taking it.

Side Effects

Metallic taste, nausea, vomiting, diarrhoea, drowsiness, rashes may be observed during treatment.

Pregnancy & Lactation

Metronidazole is classified as a pregnancy category B by the US Food and Drug Administration. However, no suitable and well-controlled studies in pregnant women have been conducted. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Human milk has been found to contain metronidazole. When Metronidazole is given to a breastfeeding mother, caution should be observed.

Precautions & Warnings

If metronidazole must be given for a longer period of time than is generally indicated, it is recommended that hematological tests, particularly leucocyte counts, be performed on a regular basis and that patients be watched for adverse responses such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures).

Patients with hepatic encephalopathy should be given metronidazole with caution.

Metronidazole might cause urine to discolor, thus patients should be cautioned.

Therapeutic Class

Amoebicides, Anti-diarrhoeal Antiprotozoal

Storage Conditions

Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.